Darwin knew that would change domestic species

Artificial selection.

Darwin knew artificial selection could change domestic species over time. He inferred that natural selection could also change species over time. In fact, he thought that if a species changed enough, it might evolve into a new species.

https://www.ck12.org/book/ck-12-biology-concepts/section/5.14/#:~:text=Therefore%2C%20he%20called%20this%20type,evolve%20into%20a%20new%20species.

this protocol provides a detailed procedure for nucleoprotein extraction from cultured cells and tissues in an efficient manner.