There are almost 500 naturally occurring variants of hemoglobin. Most are the result of a single amino acid substitution in a globin polypeptide chain. Some variants produce clinical illness, though not all variants have deleterious effects. A brief sample follows.
HbS (sickle-cell Hb): substitutes a Val for a Glu on the surface
Hb Cowtown: eliminates an ion pair involved in T-state stabilization
Hb Memphis: substitutes one uncharged polar residue for another of similar size on the surface Hb Bibba: substitutes a Pro for a Leu involved in an a helix
Hb Milwaukee: substitutes a Glu for a Val in the oxygen binding pocket
Hb Providence: substitutes an Asn for a Lys that normally projects into the central cavity of the tetramer Hb Philly: substitutes a Phe for a Tyr, disrupting hydrogen bonding at the a1b1 interface
Explain your choices for each of the following:
(a) The Hb variant least likely to cause pathological symptoms.
(b) The variant most likely to show a decrease in BPG binding and an increase in the overall affinity of the hemoglobin for oxygen.
(c) Increases the Kd of Hb for oxygen
Answers: 3
Biology, 21.06.2019 20:00
Here's one way to follow the scientific method. place the missing steps in the correct position in the process.
Answers: 3
Biology, 21.06.2019 21:20
How is mitosis different in plants and animals? a. in animals, the cell membrane pinches together. b. in plants,the dna is one circular chromosomes. c. in plants, there are no sister chromatids. d. in animals, a new cell wall forms.
Answers: 2
Biology, 22.06.2019 00:10
Why does meiosis produce cells with half the chromosomes? o a. most of the chromosomes are not necessary to keep an organism alive. b. a gamete needs only half the number of chromosomes because two gametes join together. o c. it makes the gametes easier to move around in the organism. o d. it is faster to produce gametes with fewer chromosomes.
Answers: 1
Biology, 22.06.2019 02:30
The theories on the expansion of galaxies maybe re-examined to strengthen science should not be tested to strengthen science will weaken scientific knowledge if they change will become laws if they don't change
Answers: 1
There are almost 500 naturally occurring variants of hemoglobin. Most are the result of a single ami...
Mathematics, 04.06.2020 19:16
Mathematics, 04.06.2020 19:16
English, 04.06.2020 19:16
Mathematics, 04.06.2020 19:16
Mathematics, 04.06.2020 19:16
Physics, 04.06.2020 19:16
History, 04.06.2020 19:16
Mathematics, 04.06.2020 19:16
Social Studies, 04.06.2020 19:16
History, 04.06.2020 19:16
Biology, 04.06.2020 19:16