Why is a frame shift near the start codon likely to have a greater impact than one near the stop codon?

How did the research presented in the article affect scientists' understanding of the evolution of eukaryotes

Keeping in mind the life cycle of bacteriophages, consider the following problem: during the reproductive cycle of a temperate bacteriophage, the viral dna inserts into the bacterial chromosome where the resultant prophage behaves much like a trojan horse. it can remain quiescent, or it can become lytic and initiate a burst of progeny viruses. several operons maintain the prophage state by interacting with a repressor that keeps the lytic cycle in check. insults (ultraviolet light, for example) to the bacterial cell lead to a partial breakdown of the repressor, which in turn causes the production of enzymes involved in the lytic cycle. as stated in this simple form, would you consider this system of regulation to be operating under positive or negative control?

The hematodinium parasite becomes less of a problem for the blue crab when the crab is very young. fishing is thriving in the region. the crab moves to less salty water. a significant percentage of the population is impacted.