DNA polymerase I has 5 ′ – 3 ′ polymerase activity, 5 ′ – 3 ′ exonuclease activity, and 3 ′ – 5 ′ exonuclease activity necessary for DNA replication. Mutations in the gene that encodes DNA polymerase I may cause the enzyme to lose these activities. Match the consequence of a loss‑of‑function mutation in DNA polymerase I to the corresponding lost activity.

Cancer

Explanation:

The DNA polymerase 1 is a crucial enzyme in the replication of DNA. It repairs the error in the sequences of DNA that are produces by mismatch, improper insertion or deletion. When the gene that encodes the DNA polymerase 1 gets mutated an abnormal DN polymerase 1 gets formed that has no activity of repairing. As a result of repair failure, the cell may continue to form abnormal cells by mitosis because of no checkpoints and this will lultimately lead to different type of cancers.

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