Quizlet Heparin is an anticoagulant given by injection to prevent the formation of blood clots. How does heparin work?

Heparin is a natural glycosaminoglycan that acts as an anticoagulant.

Explanation:

Heparin binds with antithrombin III (AT) which is an enzyme inhibitor that is responsible for changing the conformation.This results in activation of AT which inactivates thrombin  and other proteases.

This inactivation which is generated by AT causes increase binding of heparin  with AT through specific pentasaccharide sulfation sequence that contained heparin polymer.

The change in the conformation in AT on heparin binding mediate inhibition of Xa factor.

The binding of thrombin with heparin polymer takes place in the proximal region of the pentasaccharide.

Heparin is highly negative and thus it makes a electrostatic interaction with thrombin.

A ternary complex is formed that mainly inactivates the thrombin.

Fondaparinux acts as an anticoagulant that targets anti factor Xa activity for facilitating a stable regulation of coagulation.

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