Which of the followings is true about gluconeogenesis? A. One ATP and one GTP is needed to convert pyruvate to PEP B. Oxaloacetate is involved in generating PEP C. Gluconeogenesis primarily occurs in the mitochondria D. In occurs in the brain

The answers A, B and C are correct

Explanation:

- Gluconeogenesis primarily occurs in the mitochondria mainly in the liver.

- Oxaloacetate is used to generate PEP by a two step process.

1) conversion of Pyruvate to oxaloacetate catalyzed by pyruvate carboxylase. This process requires ATP hydrolysis.

2) The decarboxylation and phosphorylation of oxaloacetate catalyzed by phosphoenolpyruvate carboxykinase (PEPCK) producing PEP. This process requires the hydrolysis of GTP.

Therefore options A, B and C are correct.

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