What is the mechanism of synaptic transmission?

Synaptic transmission consists of three steps: (1) intracellular vesicles loaded with neurotransmitters are targeted to the presynaptic membrane; (2) an action potential triggers exocytosis to release the neurotransmitters to the synaptic cleft between two neurons

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i think the miocene epoch spans the time from 23 million to 12 million years ago.