What causes hemoglobin to unload more oxygen to metabolically active tissues such as skeletal muscles during exercise?

The Bohr Effect allows for enhanced unloading of oxygen in metabolically active peripheral tissues such as exercising skeletal muscle.  As more metabolism takes place, the carbon dioxide partial pressure increases thus causing larger reductions in local pH and in turn allowing for greater oxygen unloading.

the major parts of the digestive system:

salivary glands.

pharynx.

esophagus.

stomach.

small intestine.

large intestine.

rectum.

accessory digestive organs: liver, gallbladder, pancreas.

1. what is the relationship between the shape of an enzyme and the reactions they catalyze?

2. how does an enzyme inhibitor work?

separate your answers so i dont get confused : )