Which of the following statements are correct with regards to sulfamethoxazole/trimethoprim?
a. it is a potent hepatic enzyme inducer resulting in reduced drug concentrations.
b. it has excellent bioavailability, thus can transition from intravenous to oral formulations in a 1: 1 fashion.
c. it is active against many gram-positive pathogens, including staphylococci, gram-negative pathogens, and opportunistic pathogens.
d. this drug should be used with caution in a patient with g6pd deficiency.
e. a negative coombs test with sulfamethoxazole/trimethoprim indicates hemolytic anemia

The following statements are correct with regards to sulfamethoxazole/trimethoprim

B.) It has excellent bioavailability, thus can transition from intravenous to oral formulations in a 1:1 fashion.

C.) It is active against many Gram-positive pathogens, including Staphylococci, Gram-negative pathogens, and opportunistic pathogens.

D.) This drug should be used with caution in a patient with G6PD deficiency.

Explanation:

sulfamethoxazole/trimethoprim is an antibiotic used for the treatment of many bacterial infections. It consists of one part trimethoprim to five parts sulfamethoxazole and therefore is also called co-trimoxazole.

A positive Coombs test with sulfamethoxazole/trimethoprim indicates hemolytic anemia therefore should be discontinued. It is a potent hepatic enzyme inhibitor ( not inducer).

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