Which agent would be used to counteract a severe reaction occurring with the use of neostigmine?

Neostigmine act as Cholinesterase inhibitors.it inhibits enzyme Cholinesterase as a  competitive reversible antagonists.

This is an enzyme which normally breakdown neurotransmitter acetycholine at the neuromuscular junction (cholinergic synapses). and therefore the  termination of synaptic neurotransmission.

Acetycholine is a cholinergic  neurotransmitter that ensures transmission of cholinergic nervous signal/synapses at neuromuscular juntion.

Neostigmine inhibiting actions therefore  promotes accumulation of acetycholine  and thus extended the transmission of  cholinergic synapses,

This is expllained  the reason why   neostigmine  mechanisms is used  for  treatment of  neuromuscular disorders e.g autoimmune diseases Myasthenia graviis (weakling of body muscles.

Therfore to counter the advserse effect of Neostigmine ;

which include; salvation, head ache, increased muscus secreation,muscle itching,dizziness,

Intravenous application of  0.04mg/kg/dose of atropine sulphate  should be given with respect to each dose of Neostigmine administered.

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Explanation: