What are the features of ipsc-derived cardiomyocytes?

Explanation:

iPSC (induced Pluripotent Stem Cell) induces differentiated cardiomyocytes (cardiomyocytes, CM), which are human, good uniformity, high purity, and have unique properties of cardiomyocytes such as contractile function, action potential and ion channels.

Genetic mutation is an important factor that contributes to the pathogenesis and development of Alzheimer’s disease (AD). The genetic factors studied include the dominant mutations of genes encoding amyloid-β precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2). Additionally, more and more genes have been found to be potentially associated with AD, such as apolipoprotein E (APOE), glycogen synthase kinase 3 beta (GSK3B), dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), and Tau. Although many studies on the treatment of AD have not been successful, gene therapy is still considered as a potential way against AD, and some gene-therapy-based therapeutics have entered the clinical trial stage. Existing strategies for gene therapy against AD include gene inactivation, genetic modification, and immunoregulation, etc.

https://www.creativebiomart.net/alzheimacy/therapeutics/gene-therapy/

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