What are the problems and challenges in protein structure prediction?

The crucial problems/efforts in the field of protein structure prediction include: first, for the sequences of similar structures in PDB (especially those of weakly/distant homologous relation to the target), how to identify the correct templates and how to refine the template structure closer to the native; second

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that would be called plucking : )

explanation:

''plucking, also referred to as quarrying, is a glacial phenomenon that is responsible for the erosion and transportation of individual pieces of bedrock, especially large "joint blocks". as a glacier moves down a valley, friction causes the basal ice of the glacier to melt and infiltrate joints (cracks) in the bedrock."