Enterochromaffin-like cells of the gastric mucosa can be triggered to release histamine. histamine, in this case, causes nearby parietal cells of the stomach lining to produce hydrochloric acid. the effect of histamine on parietal cells would best be described as a(n)
a. paracrine
b. autocrine
c. exocrine
d. second messenger

The correct answer is - paracrine.

Explanation:

Parietal cells are the epithelial cells that release intrinsic factors and hydrochloric acid. The release of the HCL is triggered by the histamine which is released by the Enterochromaffin-like cells that are located in the gastric mucosa.

The effect of the histamine on parietal cells are paracrine as they communicated with the cell to cell communication and induces the change in the neighbour cells.

Thus, the correct answer is - paracrine.

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