Select the statements that characterize familial cancers. check all that apply. check all that apply they typically initiate through changes to tumor suppressor genes. they typically initiate through changes to tumor suppressor genes. they account for most cases of cancer. they account for most cases of cancer. a predisposition toward developing cancer is inherited. a predisposition toward developing cancer is inherited. loss of heterozygosity often underlies familial cancers. loss of heterozygosity often underlies familial cancers.