Sickling occurs in deoxyhemoglobin s but not in oxyhemoglobin s. oxyhemoglobin has a small, hydrophobic pocket in a β chain region located in the interior of the protein. in deoxyhemoglobin, however, this pocket is located on the surface of the protein. in deoxyhemoglobin s, val 6 interacts with this surface pocket, leading to aggregation of hbs. choose two amino acids that would be reasonable canidates for the pocket-val 6 interaction.

(a) phenylalanine
(b) leucine
(c) serine
(d) arginine
(e) glutamate