When insulin binds to its receptor, the complex is endocytosed into the cell. this is an example of in response to hormone signaling.
camp activation
generating an intracellular receptor
activation of a hormone response element
receptor down-regulation

receptor down-regulation

Explanation:

Downregulation is a control mechanism by which a cell decreases the amount of a cellular component, such as RNA or protein, in response to an external variable. In contrast, a reactive increase of a cellular component is called upregulation. An example of downregulation occurs when insulin binds to its receptor and the complex is endocyted in the cell in response to hormonal signaling.

answer:

convection currents in the magma drive plate tectonics. heat generated from the radioactive decay of elements deep in the interior of the earth creates magma (molten rock) in the aesthenosphere. the aesthenosphere (70 ~ 250 km) is part of the mantle, the middle sphere of the earth that extends to 2900 km.