How does an epigenetic change differ from a mutation? a-mutations involve nucleotide sequences of only one or a few base pairs. an epigenetic change involves large regions of a chromosome, thousands of base pairs or more in length. b-mutations can be passed on to offspring or to daughter cells. epigenetic changes cannot be inherited. c-epigenetic changes occur due to environmental effects and only persist as long as the environment that induced them remains constant. mutations are permanent. d-a mutation alters the nucleotide sequence in dna. an epigenetic change does not alter the dna sequence, but can be inherited by daughter cells.