What negative effect does sickle-cell disease have on the circulatory system?

Because sickled cells restrict blood flow, individuals can periodically experience swelling and extreme pain in any body organ or joint. This can last for hours or weeks. Sometimes permanent damage can occur to organs deprived of oxygen and nutrients

Explanation:

Red blood cells are designed to pick up oxygen in the lungs and transport it throughout the body via the circulatory system. Their donut-like shape and water-balloon-like flexibility allows them to pass through even the tiniest blood vessels.

Sickle cell anemia is a hereditary condition that causes some red blood cells to distort into rigid crescent moon shapes.

Normal red blood cells can flow freely through blood vessels. Sickled cells get stuck in the blood vessels and cause blockages.

i got something better   a catchphrase here it is

ahem  

ahem

what the squwock

explanation:

"1. it should be, it has been for about 20 years, and it's really not much different in the end than breeding animals to have particular traits. there are always concerns about genetically engineered animals/plants affecting the environment in unexpected negative ways, but i can't think of an example where the fears didn't turn out to be baseless.  

first, as you point out, it would be a great advance in pharmacology, to be able to tailor drugs and their doses to me. the pros involve better medical treatment. the cons involve privacy issues like insurance companies denying coverage to people with genetic risk factors. looking at dna markers wouldn't affect the frequency of genetic diseases, but it would allow detection of them earlier. and ok, actually i suppose that if people used this information to avoid having children with genetic diseases, some might decrease in frequency."