How is it possible that regions thousands of base pairs from a promoter can impact transcription of that gene?
a. dna is capable of looping, bringing distant regions in the same proximity. b. proteins can be very large molecules, much larger than a nucleotide. c. transcription factors work in complexes, creating large chains of proteins.

A. DNA is capable of looping, bringing distant regions in the same proximity.

Explanation:

Transcriptional factors (such as activators or repressors) are proteins that regulate gene expression by binding to DNA sequence (such as enhancers and silencers). Consequently, gene transcription might be turned on or off. Usually binding sites for transcriptional factors are located near the promoter (initiation of transcription). But when they are located far from the gene they regulate DNA, flexibility plays a role. DNA can form loops which bring together binding sites and transcription factors.

both anaerobic and aerobic respiration use glucose (or other carbohydrates), proteins and lipids to produce atp and nadh. cell uses those energy molecules, obtained from food and   breaks them down during the chemical reactions of respiration. in anaerobic respiration, nadh is regenerated to nad+ by enzymes lactate dehydrogenase (lactate is produced, e.g. in muscle cells) or by alcohol dehydrogenase where ethanol is produced (alcohol fermentation), while in aerobic respiration, electrons from nadh are deposited in the mitochondria to regenerate nad+ (electron transport chain. anaerobic respiration produces 2 atp per molecule of glucose compared to aerobic respiration where about 38 atp molecules are produced.