What is mutation in the dna sequence for the hemoglobin gene ?

Sickle cell anemia is a genetic disease with severe symptoms, including pain and anemia. The disease is caused by a mutated version of the gene that helps make hemoglobin  a protein that carries oxygen in red blood cells. People with two copies of the sickle cell gene have the disease.

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the framers of the constitution insisted that federal judges be nominated instead of elected due to their desire to have judges above the shifting whims of the masses.

the hope, whether achieved or not, was that federal judges would only be beholden to the law and that by not having judges be elected, they would be protected if that law dictated an outcome that ran counter to popular opinion.