The drug tacrolimus is used to prevent transplant rejection. predict the mechanisms of action of tacrolimus.

Tacrolimus drug has the purpose to reduce the activity of the recipient’s immune system. Tacrolimus’ mechanism includes inhibition of the production of interleukins. This is because interleukins (more precisely interleukin 2) promote the development and proliferation of T cells (T lymphocytes), which activate immune response.  

So, this drug inhibits both T cell signal transduction and IL-2 transcription.

the answer to the blank provided is “an autosomal gene that is required for the expression of genes on the x chromosome”.

testis-determining factor, abbreviated as td, which is more popularly known as sex-determining region y or sry protein, is a dna-binding protein or  gene-regulatory protein/transcription factor, encoded by the  sry gene. it is the gene responsible for the initiation of male gender determination in humans.