Drug-induced neutropenia is a disease that has significantly increased in incidence over the last several decades. what is the attributing factor in the increased incidence of drug-induced neutropenia?

The attributing factor in the increased incidence of drug-induced neutropenia is; treatment of cancer by chemotherapuetic drugs such as alkylating agents.

Drug-induced neutropenia is a condition in which there is reduction in absolute neutrophil count (ANC), caused by exposure to a medication. Drug-induced neutropenia usually occurs within the first few weeks after the introduction of drugs. Drug-induced neutropenia is a common adverse effect associated with many chemotherapy agents (drugs used in the treatment of cancer).

1. what is the relationship between the shape of an enzyme and the reactions they catalyze?

2. how does an enzyme inhibitor work?

separate your answers so i dont get confused : )