Which statement best explains the relationship between hbs allele frequency and malaria endemicity in africa? when an area is malaria free, the hbs allele frequency is between 0 and 2.02.when an area is holoendemic, the hbs allele frequency is between 0.52 and 4.04.when an area is malaria free, the hbs allele frequency is between 12.64 and 18.18.when an area is holoendemic, the hbs allele frequency is between 0 and 0.51.

When an area is holoendemic, the HbS allele frequency is between 0.52 and 4.04.

The statement that explains the relationship between HbS allele frequency and malaria endemicity in Africa is A. When an area is malaria-free, the HbS allele frequency is between 0 and 2.02.

From the two maps that are given, it can be seen the maps depict the allele frequency of sickles cell haemoglobin and the malaria endemicity in Africa.

In the regions that had no malaria outbreak, there are lighter shades of red in the heat map. This illustrates that the HbS allele frequency is between 0 and 2.02 as seen in the map.

In conclusion, the correct option is A.

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the dark variety, as they are not visible on the dark tree barks

explanation: