Make a claim about how PDC deficiency affects the amount of NADH produced by glycolysis AND the amount of NADH produced by the Krebs (citric acid) cycle in a cell. Provide reasoning to support your claims based on the position of the PDC -catalyzed reaction in the sequence of the cellular respiration pathway.

PDC deficiency directly regulates the concentration of NADH produced during glycolysis and Krebs cycle as it affects the concentration of acetyl CoA that also participate in the two vital processes.

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Glycolysis: No change - glycolysis continues PFC is not needed, glycolysis occurs before conversation of pyruvate to acetyl - CoA

Krebs Cycle: Decrease - krebs cycle greatly slowed / deceased if there isn't acetyl - CoA; Occurs after conversation of pyruvate to acetyl - CoA

Explanation:

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